Soumi Ghosh
Lab Engel Hall 204
MC0308
Education
2020- PhD Chemistry (Chemical Biology) University of Michigan, Ann Arbor, MI, USA, Principal Investigator: Dr. E. Neil G. Marsh
2014- M.Sc Chemistry, Indian Institute of Technology, Kanpur, India
2012- B.Sc Chemistry, Visva-Bharati University, Santiniketan, India
Experience
2020-2025 Postdoctoral Associate, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, Principal Investigator: Dr. Barbara Imperiali
Ghosh S., Chorghade R., Diehl R.C., Dodge G.J., Bae S., Dugan A.E., Halim M., Wuo M., Bartlett H., Herndon L.K., Kiessling L.L. (2024) “Glycan analysis probes inspired by human lectins for investigating host-microbe crosstalk”. bioRxiv.:2024-12. doi:https://doi.org/10.1101/2024.12.24.630132
Durand T., Dodge G.J., Siuda R.P., Higinbotham H.R., Arbour C.A., Ghosh S., Allen K.N., Imperiali, B. (2024) “Proteome-wide bioinformatic annotation and functional validation of the monotopic phosphoglycosyl transferase superfamily.” Proc. Natl. Acad. Sci. U.S.A.121 (49) e2417572121,
Ghosh, S., Ahearn, C.P., Isabella, C.R., Marando, V.M., Dodge, G.J., Bartlett, H., McPherson, R.L., Dugan, A.E., Jain, S., Neznanova, L. and Tettelin, H., Putnik, R., Grimes, C.L., Ruhl, S.; Kiessling, L. L., and Imperiali, B. (2023). “Human oral lectin ZG16B acts as a cell wall polysaccharide probe to decode host-microbe interactions with oral commensals”. Proc. Natl. Acad. Sci. U.S.A., 120(22), p. e2216304120. (Featured at MIT News and Kudos Research Showcase).
McPherson, R.L., Isabella, C.R., Walker, R.L., Sergio, D., Bae, S., Gaca, T., Raman, S., Nguyen, L.T.T., Wesener, D.A., Halim, M. and Wuo, M.G., Dugan, A, Kerby, R., Ghosh, S., Rey, F. E., Vlamakis, H., Alm, E. J., Xavier, R. J., Kiessling, L.L. (2023). “Lectin-Seq: a method to profile lectin-microbe interactions in native communities” Sci. Adv. 9, eadd8766
Arbour, C.A., Nagar, R., Bernstein, H.M., Ghosh, S., Al-Sammarraie, Y., Dorfmueller, H.C., Ferguson, M.A., Stanley-Wall, N. and Imperiali, B., (2023). “Defining Early Steps in B. subtilis Biofilm Biosynthesis”. mBio; doi:10.1128/mbio.00948-23.
Ward, E.M., Zamora, C.Y., Schocker, N.S., Ghosh, S., Kizer, M.E. and Imperiali, B., 2022. “Engineered Glycan-Binding Proteins for Recognition of the Thomsen–Friedenreich Antigen and Structurally Related Disaccharides”. ACS Chemical Biology, 18(1), pp.70-80. Grunkemeyer, T. J.; Ghosh, S.; Patel, A.; Sajja, K.; Windak, J.; Basrur, V.; Kim, Y.; Neshvizhkii, A. I.; Kennedy, R.T. and Marsh, E.N.G (2020) “The antiviral enzyme viperin inhibits cholesterol biosynthesis” J. Biol. Chem, 297, 100824
Ghosh, S and Marsh, E.N.G. (2020) “Viperin: an ancient radical-SAM enzyme finds its place in modern cellular metabolism and innate immunity” J. Biol. Chem, 295, 11513-11528
Ghosh, S; Patel, A; Grunkemeyer, T.J.; Dumbrepatil, A.B.; Zegalia, K; Kennedy, R.T. and Marsh, E.N.G. (2020) “Interactions between Viperin, Vesicle-Associated Membrane Protein A, and Hepatitis C Virus Protein NS5A Modulate Viperin Activity and NS5A Degradation” Biochemistry, 59, 780-789
Dumbrepatil, A.B.; Ghosh, S.; Malec, P.; Zegalia, K; Hoff, D.; Kennedy, R.T and Marsh, E. N.G (2019) “Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis” J. Biol. Chem, 294, 6888 –6898
Makins, C*; Ghosh, S*; Roman-Melendez, G.D*; Malec, P; Kennedy, R, and Marsh, E.N. (2016) “Does Viperin function as a Radical S-adenosyl-L-methionine dependent Enzyme in regulating Farnesylpyrophosphate Synthase expression and activity?” J. Biol. Chem., 291, 26806-26815 (* contributed equally)
Exploration of the eukaryotic front-line defense mechanism involved in the mucosal innate immune responses during host-pathogen interaction, using biochemical and glycobiology approaches